| datum | match | uitslag |
| 16-09-21 18u45 | R. Wien - Genk | 0 - 1 |
| 30-09-21 21u00 | Genk - Zagreb | 0 - 3 |
| 21-10-21 21u00 | West Ham - Genk | - |
| 04-11-21 18u45 | Genk - West Ham | - |
| 25-11-21 18u45 | Zagreb - Genk | - |
| 09-12-21 21u00 | Genk - R. Wien | - |
| datum | speeldag | match |
| 21-10-21 21u00 | EL GS | West Ham - Genk |
| 23-10-21 18u30 | 12 | Genk - Gent |
| 27-10-21 20u00 | 16e finale | SEW Sport - Genk |
| 31-10-21 13u30 | 13 | Z-Waregem - Genk |
| 04-11-21 18u45 | EL GS | Genk - West Ham |
| 06-11-21 18u30 | 14 | Genk - Ce. Brugge |
| 21-11-21 21u00 | 15 | Beerschot - Genk |
| 25-11-21 18u45 | EL GS | Zagreb - Genk |
| 27-11-21 18u30 | 16 | Genk - Cl. Brugge |
| 04-12-21 18u30 | 17 | Mechelen - Genk |
| ploeg | m | w | g | v | gv | gt | s | p | ||
| 1 |
 |
Cl. Brugge | 11 | 6 | 4 | 1 | 20 | 13 | 7 | 22 |
| 2 |
 |
Eupen | 10 | 6 | 2 | 2 | 21 | 12 | 9 | 20 |
| 3 |
 |
Antwerp | 10 | 6 | 2 | 2 | 20 | 13 | 7 | 20 |
| 4 |
 |
Union | 10 | 6 | 1 | 3 | 20 | 9 | 11 | 19 |
| 5 |
 |
Genk | 10 | 5 | 2 | 3 | 21 | 15 | 6 | 17 |
| 6 |
 |
Mechelen | 10 | 5 | 1 | 4 | 18 | 19 | -1 | 16 |
| 7 |
 |
Anderlecht | 10 | 4 | 4 | 2 | 19 | 12 | 7 | 16 |
| 8 |
 |
Kortrijk | 11 | 4 | 3 | 4 | 14 | 14 | 0 | 15 |
| 9 |
 |
STVV | 10 | 4 | 2 | 4 | 10 | 12 | -2 | 14 |
| 10 |
 |
Oostende | 10 | 4 | 2 | 4 | 14 | 18 | -4 | 14 |
| 11 |
 |
Charleroi | 10 | 3 | 5 | 2 | 17 | 13 | 4 | 14 |
| 12 |
 |
Standard | 10 | 4 | 1 | 5 | 10 | 17 | -7 | 13 |
| 13 |
 |
Seraing | 10 | 4 | 0 | 6 | 13 | 17 | -4 | 12 |
| 14 |
 |
Gent | 10 | 3 | 2 | 5 | 16 | 13 | 3 | 11 |
| 15 |
 |
Z-Waregem | 10 | 2 | 3 | 5 | 15 | 23 | -8 | 9 |
| 16 |
 |
OH Leuven | 10 | 1 | 6 | 3 | 9 | 17 | -8 | 9 |
| 17 |
 |
Ce. Brugge | 10 | 2 | 2 | 6 | 11 | 16 | -5 | 8 |
| 18 |
 |
Beerschot | 10 | 0 | 2 | 8 | 7 | 22 | -15 | 2 |
